Identification of a New Target for Colon Cancer Therapy

Grant number: 508908 | Funding period: 2008 - 2011

Completed

Abstract

Increased level of PAK1(a protein kinase) was associated with the progression of colorectal (large bowel) cancer (CRC). Gastrin peptides are growth factors responsible for CRC development. The objective of this project is to determine the role of PAK1 in the regulation of CRC growth and metastasis by gastrin peptides. We will use cell culture, animal models and clinical samples in the program. A successful outcome will lead to the development of new CRC therapies such as inhibitors of PAK1.

Related publications (10)

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D Yeo, N Huynh, JA Beutler, GS Baldwin, H He, M Nikfarjam

2016-11-01

Background: Pancreatic cancer continues to have a poor survival rate with an urgent need for improved treatments. Glaucarubinone, ..

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

D Yeo, H He, O Patel, AM Lowy, GS Baldwin, M Nikfarjam

2016-01-16

Background: Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumours. Treatment options are limited an..

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway

N Huynh, JA Beutler, A Shulkes, GS Baldwin, H He

2015-01-01

p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PA..

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

D Yeo, N Huynh, JA Beutler, C Christophi, A Shulkes, GS Baldwin, M Nikfarjam, H He

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Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas...

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells

N Huynh, KH Liu, M Yim, A Shulkes, GS Baldwin, H He

2014-01-01

Gastrins, including amidated gastrin17 and glycine-extended gastrin17, are important growth factors in colorectal cancer (CRC). Th..

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α

KH Liu, N Huynh, O Patel, A Shulkes, G Baldwin, H He

2013-10-28

P21 activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin and Ras oncogene, which pr..

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways

N Huynh, M Yim, J Chernoff, A Shulkes, GS Baldwin, H He

2013-06-10

Gastrins, including amidated (Gamide) and glycine-extended (Ggly) forms, function as growth factors for the gastrointestinal mucos..

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth

H He, N Huynh, KH Liu, C Malcontenti-Wilson, J Zhu, C Christophi, A Shulkes, GS Baldwin

2012-04-01

The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were ..

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

N Huynh, KH Liu, GS Baldwin, H He

2010-09-01

The p21-activated kinase (PAK) family of serine/threonine kinases plays an important role in cell proliferation, survival and moti..

Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins

H He, GS Baldwin

2008-05-15

Gastrins, including amidated gastrin (Gamide) and glycine-extended gastrin (Ggly), accelerate the growth of gastrointestinal cance..

University of Melbourne Researchers

Hong He